54 articles - From Friday Sep 08 2023 to Friday Sep 15 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Cirrhotic cardiomyopathy influences clinical outcomes and enhances performance of conventional risk prediction models in acute-on-chronic liver failure with severe sepsis. POC-Echo measurements such as CCM markers (E/e' and e' velocity) and change in CI reliably predict circulatory failure and mortality in ACLF with severe sepsis. CCM markers significantly enhanced the CLIF-C ACLF and MELDNa predictive performance. |
MEFIB-Index and MAST-Score in the assessment of hepatic decompensation in metabolic dysfunction-associated steatosis liver disease-Individual participant data meta-analyses. A combination of MRI-based biomarker and blood tests, MEFIB-Index and MAST-Score can predict the risk of hepatic decompensation in patients with MASLD. |
Tenofovir disoproxil fumarate versus tenofovir alafenamide on risk of osteoporotic fracture in patients with chronic hepatitis B: A nationwide claims study in South Korea. TAF-treated patients with CHB had a significantly lower risk of osteoporotic fracture than TDF-treated patients. |
Waitlist and post-transplant outcomes among candidates listed for liver transplant: Liver alone versus simultaneous liver kidney listings. Among candidates with renal dysfunction at listing for LT, those listed for LT alone should receive transplant promptly to optimise waitlist outcomes. Those listed for SLK should wait to receive both organs to optimise post-transplant outcomes. |
| Clin Gastroenterol Hepatol |
Anti-Mullerian Hormone, a Marker of Ovarian Reserve, Is Protective Against Presence and Severity of NASH in Premenopausal Women. AMH may reflect a unique biomarker of NASH in premenopausal women and findings suggest a novel link between reproductive aging and histologic severity of NAFLD in women. |
Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions. Being breastfed in infancy was associated with increased risk of CRC in adulthood, including among younger adults. However, further research is needed to understand the underlying biological mechanisms, as this association does not establish causation. |
Incidence of Etiology-specific Hepatocellular Carcinoma: diverging trends and significant heterogeneity by race and ethnicity. New directly acting anti-viral drugs have impacted rates of HCV-HCC, offsetting important increases in both ALD- and NAFLD-HCC. Hispanics may be a group of concern due to higher rates for ALD- and NAFLD-HCC. HCC etiology varies remarkably and may warrant specific interventions by detailed race-ethnicity. |
Loneliness and Depressive Symptoms are High Among Older Adults with Digestive Disease and associated with Lower Perceived Health. Older adults with a digestive disease were more likely than those without a digestive disease to endorse loneliness and moderate-to-severe depression and these conditions are associated with poor-or-fair health. Gastroenterologists should feel empowered to screen patients for depression and loneliness symptoms and establish care pathways for mental health treatment. |
Optimizing the management algorithm for heartburn in general gastroenterology: Cost-effectiveness and cost-minimization analysis. Among patients with heartburn, endoscopy with ambulatory reflux monitoring (OFF-PPI) optimizes cost-effective management by matching treatment to phenotype. When erosive findings are absent, trialing PPI discontinuation is more cost-effective than optimizing PPI. |
| Endoscopy |
A machine learning-based choledocholithiasis prediction tool improves ERCP decision making - a proof of concept study. A machine learning-based tool was created that provides a real-time, personalized, objective probability of choledocholithiasis and ERCP recommendations. This more accurately directs ERCP use than the existing ASGE and ESGE guidelines and has the potential to reduce morbidity and healthcare costs associated with ERCP or missed choledocholithiasis. |
| Gastroenterology |
Antireflux surgery versus antireflux medication and risk of esophageal adenocarcinoma in patients with Barrett's esophagus. Patients with Barrett's esophagus who undergo antireflux surgery do not seem to have a lower risk of esophageal adenocarcinoma than those using antireflux medication. |
Standardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study. We developed standardized recommendations for clinical trial design, eligibility criteria, outcome measures, gluten challenge, and disease evaluations for RCTs in patients with CeD. |
Traditional Medicine Pien Tze Huang Suppresses Colorectal Tumorigenesis through Restoring Gut Microbiota and Metabolites. PZH manipulated gut microbiota and metabolites toward a more favorable profile, improves gut barrier function, and suppresses oncogenic and pro-inflammatory pathways, thereby suppressing colorectal carcinogenesis. |
| Gastrointest Endosc |
ERCP using balloon-assisted endoscope versus EUS-guided treatment for common bile duct stones in Roux-en-Y gastrectomy. The 1-year recurrence rate was 8.3% in both groups. Effectiveness and safety of BE-ERCP and EUS-AG were comparable in CBD stone removal for patients after R-Y gastrectomy, but complete stone removal after technical success was superior in BE-ERCP. |
| Gut |
DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma. The success of machine-learning to identify an effective marker signature documents the power of this approach. The high diagnostic accuracy of discriminating PDAC from CP could have tremendous consequences for treatment success, once the result from still a limited number of liquid biopsy samples would be confirmed in a larger cohort of patients with suspected pancreatic cancer. |
Enhanced antitumour immunity following neoadjuvant chemoradiotherapy mediates a favourable prognosis in women with resected pancreatic cancer. PDAC tumours of women are more sensitive to gemcitabine-based nCRT, resulting in longer OS after resection compared with men. This may be due to enhanced immunity impeding the infiltration of protumoral M2 macrophages into the TME. Our findings highlight the importance of considering sex disparities and mitigating immunosuppressive macrophage polarisation for personalised PDAC treatment. |
| Hepatology |
LIM domain only 7 negatively controls non-alcoholic steatohepatitis in the setting of hyperlipidaemia. These findings provide proof-of-concept evidence supporting LMO7 as a robust suppressor of NASH in the context of hyperlipidemia, indicating that targeting the LMO7-TRIM47 axis is a promising therapeutic strategy for NASH. |
Lack of complete biochemical response in autoimmune hepatitis leads to adverse outcome: first report of the IAIHG retrospective registry. The IAIHG-RR represents the world's largest AIH cohort with moderate-to-good data quality and a relevant number of liver-related events. The registry is a suitable platform for patient selection in future studies. Lack of complete biochemical response to treatment, non-white ethnicity, cirrhosis and PSC-AIH were associated with liver-related death and liver transplantation. |
Pegylated interferon-a for chronic hepatitis B…not ready to be shelved yet! new insights on its role using single-cell transcriptomics. The current editorial reviews a recent study related to the in-vivo use of PegIFN-a using single-cell RNA sequencing (scRNA-seq) technology. PegIFN-a reverts the transcriptome profile of treated samples close to that of the healthy population, diminishing the pro-inflammatory genes and 'inflammatory scores' which will be important for the HBV-cure program. |
Single-cell immune profiling of mouse liver aging reveals Cxcl2+ macrophages recruit neutrophils to aggravate liver injury. This in-depth study illustrates that the mechanism of Cxcl2+ macrophage-driven neutrophil activation involves the CXCL2-CXCR2 axis, and provide a potential therapeutic strategy for age-related liver injury. |
The rapidly evolving landscape of HCC: Selecting the optimal systemic therapy. In addition, predictive biomarkers for successful patients' stratification are yet to be available and constitute the focus of ongoing research. The treatment algorithm is likely to become even more complex since systemic therapeutic approaches are now being translated into earlier stages of the disease, with an impact on the evolution of the sequential treatment of HCC patients. |
| J Hepatol |
AFP-L3 and DCP Strongly Predict Early Hepatocellular Carcinoma Recurrence After Liver Transplantation. Dual-positivity for AFP-L3 =15% and DCP =7.5 strongly predicted post-LT HCC recurrence. This model could refine LT selection criteria and identify high-risk HCC patients to receive additional LRT with LT on hold until biomarker reduction is achieved. |
Hepatic steatosis aggravates atherosclerosis via small extracellular vesicle-mediated inhibition of cellular cholesterol efflux. Steatotic hepatocytes-derived sEVs promote foam cells formation and facilitate atherogenesis by miR-30a-3p/ABCA1 axis. Targeting and reducing hepatic steatotic sEVs secretion or miR-30a-3p may be potential therapeutic approaches to slow the NAFLD-driven AS progression. Impact and implications The prevalence of non-alcoholic fatty liver disease (NAFLD) is associated with atherosclerosis (AS). However, the key molecular mechanism of how NAFLD affects atherosclerosis progression is still unclear. Herein, we identified small extracellular vesicles (sEVs) from steatotic hepatocytes as a trigger to accelerate AS progression. Steatotic hepatocytes-derived sEVs promoted foam cells formation via miR-30a-3p/ABCA1 axis. Our findings not only provide mechanistic insight into NAFLD-driven AS but also provide potential therapeutic targets for AS patients. |
Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC Collectively, our results revealed a fundamental mechanism involving CD10 + ALPL + NEUs for tumor immune escape from durable anti-PD-1 treatment and provided further insights into immunotherapy targets or anti-PD-1 synergistic treatment regimens. Impact and implications Herein, we discovered that tumor cells reprogrammed CD10 + ALPL + NEUs to induce the "irreversible" exhaustion of T cells and hence allow the tumors to escape from the intended effects of anti-PD-1 treatment. Our data provided a new theoretical basis for the elucidation of special cell populations and a molecular mechanism underpinning resistance to immunotherapy. Targeting these cells contributed to evaluating indications for immunotherapy and could be looked at as a potentially more effective therapeutic approach. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
Cannabinoids and the GI Tract. The synthesis and degradation of endocannabinoids, location of cannabinoid (CB) receptors, and cannabinoid mechanisms of action on immune/inflammatory, neuromuscular, and sensory functions in digestive organs are well documented. CB mechanisms, have potential for inflammatory, gastroparesis, and pain disorders; however, the trials require replication and further understanding of risk-benefit to enhance use of cannabinoids in gastrointestinal diseases. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Clin Gastroenterol Hepatol |
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| Endoscopy |
| Gastroenterology |
| Gut |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gut |
| J Hepatol |